One thing to remember with VirusTotal is that it should only be used as a “tool of consensus”. A lot of AV solutions on their list will false flag binaries presumably to instill fear and get people to buy their solutions over more reputable AV providers. You want the AV that works the best which many people would equate to the most flagging (as logically incomplete as that may be).
If you are seeing 66 flags and many of those being from reputable vendors, then I would say that what they show is likely accurate. Accuracy and relevance being two different things. 100% accuracy on keygen tools doesn’t mean that it is a relevant flag to what you’re trying to do.
You could try software solutions like LOKI (the IoC scanner) or Azul to test specific binaries, though. I believe LOKI is just doing static analysis, but Azul I know automates the sandboxing.
Denuvo CEO: “Well, actually, it makes things faster. We streamline the process through several other processes to output the same result. We like to think of it as a fun multiplier. That’s how Denuvo math works here.”