First author Dr. Olivia Bracken (UCL Department of Ageing, Rheumatology and Regenerative Medicine) said: "Our findings reveal a natural pathway that limits harmful immune cell expansion and helps calm inflammation more quickly.
“Targeting this mechanism could lead to safer treatments that restore immune balance without suppressing overall immunity. With chronic inflammation ranked as a major global health threat, this discovery opens a promising avenue for new therapies.”
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- 6 days
Title: Scientists discover hidden switch that shuts down inflammation.
In the article: “The treatment did not, however, significantly change outward signs such as redness or swelling.”
Uhh…
- Donn@slrpnk.netEnglish6 days
Blocking sEH increased epoxy-oxylipin levels, helped pain resolve more quickly, and sharply reduced the number of intermediate monocytes found in both the blood and tissue. These immune cells have been linked to persistent inflammation and the progression of inflammatory disease.
redness/swelling aren’t the only markers of inflammation in this context, as the cells that kick off the response do more harm than good when they wear out their welcome.
monocytes are white blood cells that develop in bone marrow. i’m curious/interested in whether the same treatment affects mast cells that develop in connective tissue
6 daysWhat’s the opposite of inflammation? Can it go too far in the other direction?
- 6 days
Yes. Studies show that nonsteroidal anti-inflammatory drugs like Advil and Tylenol can actually supress gains in the gym if taken in excess because the natural muscle breakdown, inflammation, and response mechanism is blunted. Same is true for ice baths. So, sometimes swelling and inflammation can be a good thing that we want to occur.
Also staying on prednisone and other steroids too long to supress inflammation leads to all kinds of issues.
- village604@adultswim.fanEnglish5 days
Tylenol is not an NSAID. It doesn’t work on inflammation.
Also, there was a study a year or so ago that found evidence that Ibuprofen after working out helped speed recovery times.
- 3 days
Speeding recovery times has a tradeoff though. It may be negligible but I heard on an exercise science podcast of some kind that it blunts the recovery process so if maximizing muscle growth is your goal, don’t overdo nsaids.
However, like you said, if you’re an NFL athlete during the season then recovery is the priority over muscle growth and then ice baths and nsaids and inflammation reducing things are worth the trade off.
My mistake on Tylenol being an nsaid. Obvious hindsight. Brain fart.
